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Issue 41, 2014
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ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response

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Abstract

A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineering applications.

Graphical abstract: ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response

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Publication details

The article was received on 05 Jul 2014, accepted on 09 Sep 2014 and first published on 24 Sep 2014


Article type: Communication
DOI: 10.1039/C4TB01094A
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Citation: J. Mater. Chem. B, 2014,2, 7109-7113
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    ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response

    S. H. Lee, T. C. Boire, J. B. Lee, M. K. Gupta, A. L. Zachman, R. Rath and H. Sung, J. Mater. Chem. B, 2014, 2, 7109
    DOI: 10.1039/C4TB01094A

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