Jump to main content
Jump to site search

Issue 35, 2014
Previous Article Next Article

Blood compatible materials: state of the art

Author affiliations

Abstract

Devices that function in contact with blood are ubiquitous in clinical medicine and biotechnology. These devices include vascular grafts, coronary stents, heart valves, catheters, hemodialysers, heart-lung bypass systems and many others. Blood contact generally leads to thrombosis (among other adverse outcomes), and no material has yet been developed which remains thrombus-free indefinitely and in all situations: extracorporeally, in the venous circulation and in the arterial circulation. In this article knowledge on blood–material interactions and “thromboresistant” materials is reviewed. Current approaches to the development of thromboresistant materials are discussed including surface passivation; incorporation and/or release of anticoagulants, antiplatelet agents and thrombolytic agents; and mimicry of the vascular endothelium.

Graphical abstract: Blood compatible materials: state of the art

Back to tab navigation

Publication details

The article was received on 31 May 2014, accepted on 16 Jul 2014 and first published on 17 Jul 2014


Article type: Feature Article
DOI: 10.1039/C4TB00881B
Citation: J. Mater. Chem. B, 2014,2, 5718-5738
  •   Request permissions

    Blood compatible materials: state of the art

    X. Liu, L. Yuan, D. Li, Z. Tang, Y. Wang, G. Chen, H. Chen and J. L. Brash, J. Mater. Chem. B, 2014, 2, 5718
    DOI: 10.1039/C4TB00881B

Search articles by author

Spotlight

Advertisements