Jump to main content
Jump to site search

Issue 24, 2014
Previous Article Next Article

Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols

Author affiliations

Abstract

We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol–oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT–OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT–OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.

Graphical abstract: Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Apr 2014, accepted on 22 Apr 2014 and first published on 23 Apr 2014


Article type: Communication
DOI: 10.1039/C4TB00573B
Citation: J. Mater. Chem. B, 2014,2, 3741-3744
  • Open access: Creative Commons BY license
  •   Request permissions

    Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols

    J. Murray, D. Nowak, L. Pukenas, R. Azhar, M. Guillorit, C. Wälti, K. Critchley, S. Johnson and R. S. Bon, J. Mater. Chem. B, 2014, 2, 3741
    DOI: 10.1039/C4TB00573B

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements