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Issue 17, 2014
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A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

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Abstract

Engineering of anisotropic tissues demands extracellular matrix (ECM) mimicking scaffolds with an asymmetric distribution of functionalities. We here describe a convenient, modular approach based on supramolecular building blocks to form electrospun bilayered scaffolds with tailorable properties. Polymers and peptides functionalized with hydrogen-bonding ureido-pyrimidinone (UPy) moieties can easily be mixed-and-matched to explore new material combinations with optimal properties. These combinatorial supramolecular biomaterials, processed by electrospinning, enable the formation of modular fibrous scaffolds. We demonstrate how UPy-functionalized polymers based on polycaprolactone and poly(ethylene glycol) enable us to unite both cell-adhesive and non-cell adhesive characters into a single electrospun bilayered scaffold. We furthermore show that the non-cell adhesive layer can be bioactivated and made adhesive for kidney epithelial cells by the incorporation of 4 mol% of UPy-modified Arg-Gly-Asp (RGD) peptide in the electrospinning solution. These findings show that the UPy-based supramolecular biomaterial system offers a versatile toolbox to form modular multilayered scaffolds for tissue engineering and regenerative medicine applications such as the formation of membranes for a living bioartificial kidney.

Graphical abstract: A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

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Publication details

The article was received on 28 Oct 2013, accepted on 04 Feb 2014 and first published on 04 Feb 2014


Article type: Paper
DOI: 10.1039/C3TB21516D
Citation: J. Mater. Chem. B, 2014,2, 2483-2493
  • Open access: Creative Commons BY license
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    A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

    B. B. Mollet, M. Comellas-Aragonès, A. J. H. Spiering, S. H. M. Söntjens, E. W. Meijer and P. Y. W. Dankers, J. Mater. Chem. B, 2014, 2, 2483
    DOI: 10.1039/C3TB21516D

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