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Issue 17, 2014
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Mitochondrial targeting dendrimer allows efficient and safe gene delivery

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Abstract

Cationic dendrimers are promising tools in the introduction of nucleic acids into mammalian cells, however, present dendrimer-based gene vectors have modest transfection efficacy and significant toxicity. Here, we synthesized triphenylphosphonium (TPP) conjugated dendrimers and used them as polymeric gene vectors. TPP-conjugated dendrimers can effectively target mitochondria and showed efficient transfection efficacy on HeLa and COS-7 cells with low cytotoxicity on the transfected cells. These materials achieved much higher efficacy than the commercial transfection reagent SuperFect and comparable efficacy with Lipofectamine 2000. This study provides a new insight into the design of efficient and biocompatible gene vectors using dendrimers as scaffolds.

Graphical abstract: Mitochondrial targeting dendrimer allows efficient and safe gene delivery

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Publication details

The article was received on 29 Sep 2013, accepted on 22 Nov 2013 and first published on 28 Nov 2013


Article type: Paper
DOI: 10.1039/C3TB21348J
Citation: J. Mater. Chem. B, 2014,2, 2546-2553
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    Mitochondrial targeting dendrimer allows efficient and safe gene delivery

    X. Wang, N. Shao, Q. Zhang and Y. Cheng, J. Mater. Chem. B, 2014, 2, 2546
    DOI: 10.1039/C3TB21348J

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