Issue 42, 2014
From the journal:

Soft Matter

Molecular recognition of nucleic acids by nucleolipid/dendrimer surface complexes†

Marianna Yanez Arteta,a   Debora Berti,b   Costanza Montis,b   Richard A. Campbell,c   Luke A. Clifton,d   Maximilian W. A. Skoda,d   Olaf Soltwedel,e   Piero Baglioni*b  and  Tommy Nylander*a  

* Corresponding authors

a Physical Chemistry, Department of Chemistry, Lund University, P. O. Box 124, S-221 00 Lund, Sweden
E-mail: Tommy.Nylander@fkem1.lu.se

b CSGI and Department of Chemistry Ugo Schiff, University of Florence, Florence, Italy
E-mail: baglioni@csgi.unifi.it

c Institut Laue-Langevin, 71 avenue des Martyrs, 38042 Grenoble Cedex 9, France

d ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell, Oxfordshire OX11 OQX, UK

e Max-Planck-Institute for Solid State Research, Outstation at MLZ, Lichtenbergstr. 1, 85747 Garching, Germany

Abstract

We show for the first time that 1,2-dilauroyl-sn-glycero-3-phosphatidyladenosine nucleolipid surface complexes with cationic poly(amidoamine) dendrimers can be used to selectively bind DNA including oligonucleotides. This molecular recognition has high potential for applications involving biomedical and bioanalytic devices as well as drug delivery systems based on nucleic acids.

Graphical abstract: Molecular recognition of nucleic acids by nucleolipid/dendrimer surface complexes

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Article information

DOI
https://doi.org/10.1039/C4SM01733A
Article type
Communication
Submitted
05 Aug 2014
Accepted
05 Sep 2014
First published
05 Sep 2014

Soft Matter, 2014,10, 8401-8405

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Molecular recognition of nucleic acids by nucleolipid/dendrimer surface complexes

M. Y. Arteta, D. Berti, C. Montis, R. A. Campbell, L. A. Clifton, M. W. A. Skoda, O. Soltwedel, P. Baglioni and T. Nylander, Soft Matter, 2014, 10, 8401 DOI: 10.1039/C4SM01733A

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