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Issue 39, 2014
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A microfluidic device to sort capsules by deformability: a numerical study

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Abstract

Guided by extensive numerical simulations, we propose a microfluidic device that can sort elastic capsules by their deformability. The device consists of a duct embedded with a semi-cylindrical obstacle, and a diffuser which further enhances the sorting capability. We demonstrate that the device can operate reasonably well under changes in the initial position of the capsule. The efficiency of the device remains essentially unaltered under small changes of the obstacle shape (from semi-circular to semi-elliptic cross-section). Confinement along the direction perpendicular to the plane of the device increases its efficiency. This work is the first numerical study of cell sorting by a realistic microfluidic device.

Graphical abstract: A microfluidic device to sort capsules by deformability: a numerical study

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Publication details

The article was received on 20 May 2014, accepted on 20 Jun 2014 and first published on 20 Jun 2014


Article type: Paper
DOI: 10.1039/C4SM01097C
Citation: Soft Matter, 2014,10, 7705-7711
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    A microfluidic device to sort capsules by deformability: a numerical study

    L. Zhu, C. Rorai, Dhrubaditya Mitra and L. Brandt, Soft Matter, 2014, 10, 7705
    DOI: 10.1039/C4SM01097C

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