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Issue 6, 2014
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Lateral surface engineering of hybrid lipid–BCP vesicles and selective nanoparticle embedding

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Abstract

Bio-inspired recognition between macromolecules and antibodies can be used to reveal the location of amphiphilic block copolymers (BCPs) in model biomembranes and their subsequent scaffolding with nanoparticles (NPs). Potential applications of this novel class of lipid–BCP membranes require an understanding of their compositional heterogeneities with a variety of different molecules including natural proteins or synthetic NPs, whose selective incorporation into a specific part of phase separated membranes can serve as a model system for the targeted delivery of therapeutics. We demonstrate the selective incorporation of polymer-functionalized CdSe NPs into the polymer-rich domains in vesicular hybrid membranes using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, Tm = 41 °C) or 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC, Tm = −20 °C) as the lipid component. Furthermore, we demonstrate a method to detect PIB–PEO based amphiphilic BCPs on liposomal surfaces by a PEO binding antibody (anti-PEO). As a result, hybrid membrane morphologies, which depend on the lipid/BCP composition, are selectively monitored and engineered.

Graphical abstract: Lateral surface engineering of hybrid lipid–BCP vesicles and selective nanoparticle embedding

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Publication details

The article was received on 29 Jul 2013, accepted on 07 Nov 2013 and first published on 11 Nov 2013


Article type: Paper
DOI: 10.1039/C3SM52040D
Citation: Soft Matter, 2014,10, 831-839
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    Lateral surface engineering of hybrid lipid–BCP vesicles and selective nanoparticle embedding

    M. Schulz, A. Olubummo, K. Bacia and W. H. Binder, Soft Matter, 2014, 10, 831
    DOI: 10.1039/C3SM52040D

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