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Edge Article

Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogs

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a
Department of Chemistry, Université de Montréal, CP 6128 Succ. Centre-Ville, Montréal, Canada
E-mail: stephen.hanessian@umontreal.ca
b
Department of Materials and Life Sciences, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo, Japan
c
Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, United States
Chem. Sci., 2014,5, 4621-4632

DOI: 10.1039/C4SC01626B
Received 02 Jun 2014, Accepted 16 Jul 2014
First published online 27 Aug 2014
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