Jump to main content
Jump to site search

Issue 9, 2014
Previous Article Next Article

Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

Author affiliations

Abstract

Blood type mismatching is a critical problem in blood transfusions and it occasionally leads to severe transfusion reactions and even patient death. Inspired by the adhesive proteins secreted by mussels, we suggest a catecholic chemistry-based strategy to shelter antigenic epitopes on red blood cells (RBCs) by using polydopamine (PDA), which can guard against coagulation reaction without other negative effects on the RBC structure, function and viability. Both in vitro and in vivo studies confirm that the PDA-engineered RBCs (PDA-RBCs) can be applied in blood transfusion practices. The systemic assessment using a murine model demonstrates that the modified RBCs have a perfect survival profile even with repeated transfusion and high transfusion rates up to around 60%. It follows that an appropriate biogenic-chemical modification can produce antigenically shielded universal RBCs and provide insight for cell transplantation by using cell surface engineering.

Graphical abstract: Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 16 Apr 2014, accepted on 15 May 2014 and first published on 15 May 2014


Article type: Edge Article
DOI: 10.1039/C4SC01120A
Citation: Chem. Sci., 2014,5, 3463-3468
  •   Request permissions

    Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

    B. Wang, G. Wang, B. Zhao, J. Chen, X. Zhang and R. Tang, Chem. Sci., 2014, 5, 3463
    DOI: 10.1039/C4SC01120A

Search articles by author