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Issue 8, 2014
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Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

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Abstract

A nanosized M12L24 coordination sphere mimicking a histone-octamer, in size and charge density, was studied as an artificial DNA compaction core. It triggered a stepwise condensation process in a similar manner to that of the natural system. “Beads-on-a-string” and “multistrand aggregation” intermediates were clearly observed by atomic force microscopy (AFM) and dynamic light scattering (DLS) studies during the condensation process.

Graphical abstract: Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

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Publication details

The article was received on 03 Mar 2014, accepted on 13 Mar 2014 and first published on 29 Apr 2014


Article type: Edge Article
DOI: 10.1039/C4SC00656A
Citation: Chem. Sci., 2014,5, 3257-3260
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    Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

    T. Kikuchi, S. Sato, D. Fujita and M. Fujita, Chem. Sci., 2014, 5, 3257
    DOI: 10.1039/C4SC00656A

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