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Issue 7, 2014
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Single molecule analysis of light-regulated RNA:spiropyran interactions

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Abstract

The photo-regulated interactions between an RNA aptamer and photochromic spiropyran were investigated at a single-molecule level via an α-hemolysin nanopore. Upon irradiation of alternating UV/visible light, the translocation process of the RNA aptamer could be optically tuned on account of its different binding affinity with two photoisomers, spiropyran and merocyanine. This provides a general analytic model for understanding the mechanism of a photo-regulated biomolecule conformational change at a single-molecule level.

Graphical abstract: Single molecule analysis of light-regulated RNA:spiropyran interactions

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Publication details

The article was received on 14 Jan 2014, accepted on 06 Mar 2014 and first published on 07 Mar 2014


Article type: Edge Article
DOI: 10.1039/C4SC00134F
Citation: Chem. Sci., 2014,5, 2642-2646
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    Single molecule analysis of light-regulated RNA:spiropyran interactions

    X. Zhang, J. Zhang, Y. Ying, H. Tian and Y. Long, Chem. Sci., 2014, 5, 2642
    DOI: 10.1039/C4SC00134F

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