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Issue 3, 2014
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Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

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Abstract

Application of mild hyperthermia can increase the cytotoxicity of anticancer drugs in tumour cells. In this report, we describe low molecular weight thermoactive ruthenium-based drugs with fluorous chains that are selectively triggered by mild hyperthermia. The organometallic complexes were prepared, characterized, and evaluated for their in vitro cytotoxicity against a panel of human cancer cell lines and non-cancerous immortalized cells. The compounds show considerable chemo-thermal selectivity towards cancer cells (ca. 5 μM versus >500 μM for healthy cells) for the compound with the longest fluorous chain.

Graphical abstract: Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

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Publication details

The article was received on 19 Nov 2013, accepted on 23 Dec 2013 and first published on 02 Jan 2014


Article type: Edge Article
DOI: 10.1039/C3SC53185F
Citation: Chem. Sci., 2014,5, 1097-1101
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    Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

    C. M. Clavel, E. Păunescu, P. Nowak-Sliwinska and P. J. Dyson, Chem. Sci., 2014, 5, 1097
    DOI: 10.1039/C3SC53185F

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