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Issue 12, 2014
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Late-stage [18F]fluorination: new solutions to old problems

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Abstract

The last 2–3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These collaborations have led to the development of many new strategies for the late-stage introduction of fluorine-18 into complex bioactive molecules. In this perspective we highlight recent developments and key milestones since 2011.

Graphical abstract: Late-stage [18F]fluorination: new solutions to old problems

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Publication details

The article was received on 15 Jul 2014, accepted on 21 Aug 2014 and first published on 25 Aug 2014


Article type: Perspective
DOI: 10.1039/C4SC02099E
Author version available: Download Author version (PDF)
Citation: Chem. Sci., 2014,5, 4545-4553
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    Late-stage [18F]fluorination: new solutions to old problems

    A. F. Brooks, J. J. Topczewski, N. Ichiishi, M. S. Sanford and P. J. H. Scott, Chem. Sci., 2014, 5, 4545
    DOI: 10.1039/C4SC02099E

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