Jump to main content
Jump to site search

Issue 9, 2014
Previous Article Next Article

Multi-step and multi-component organometallic synthesis in one pot using orthogonal mechanochemical reactions

Author affiliations

Abstract

We demonstrate that the mechanochemical strategies for oxidative addition and ligand substitution on organometallic centers can be mutually orthogonal, permitting the rational design of multi-component mechanochemical reaction procedures for assembling complex or solution-sensitive organometallic species from three, four or even five components in one pot. The herein established synthetic procedures represent a new level of complexity in mechanochemical reactions by milling and are the first to combine redox and ligand substitution reactions into mechanochemical strategies for either one-pot sequential (“telescoping”) or one-pot multi-component syntheses. This ability to combine mechanochemical transformations has enabled the solvent-free, room-temperature syntheses of relatively complex organometallics directly for simple zerovalent metal carbonyls as the simplest precursors. In particular, we demonstrate the efficiency of mechanochemical oxidative addition by targeting selected pentacarbonyl halides (fluoride, chloride, bromide, iodide) of rhenium(I) and manganese(I), and illustrate the potential of multi-step organometallic mechanochemistry in the syntheses of selected fac-tricarbonyl complexes of these metals.

Graphical abstract: Multi-step and multi-component organometallic synthesis in one pot using orthogonal mechanochemical reactions

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 May 2014, accepted on 16 Jun 2014 and first published on 16 Jun 2014


Article type: Edge Article
DOI: 10.1039/C4SC01252F
Citation: Chem. Sci., 2014,5, 3576-3582
  •   Request permissions

    Multi-step and multi-component organometallic synthesis in one pot using orthogonal mechanochemical reactions

    J. G. Hernández, I. S. Butler and T. Friščić, Chem. Sci., 2014, 5, 3576
    DOI: 10.1039/C4SC01252F

Search articles by author