Issue 88, 2014

Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Abstract

The synthesis of peptide alcohols from peptides bearing C-terminal amide using β-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.

Graphical abstract: Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Supplementary files

Article information

Article type
Paper
Submitted
22 Aug 2014
Accepted
19 Sep 2014
First published
22 Sep 2014

RSC Adv., 2014,4, 47841-47847

Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

K. Thalluri, A. Paul, S. R. Manne, D. Dev and B. Mandal, RSC Adv., 2014, 4, 47841 DOI: 10.1039/C4RA09091H

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