Issue 86, 2014

The construction of cell-density controlled three-dimensional tissues by coating micrometer-sized collagen fiber matrices on single cell surfaces

Abstract

Type I collagen fibers were coated onto single cell surfaces by capitalizing on the formation of collagen microfibers at a neutral pH and exploiting cell membrane interactions between collagen fibers and integrin receptors. Collagen fiber coat thicknesses were controllable from 3 to 30 μm. Multi-layered tissues with controllable thicknesses and cell densities were successfully constructed depending on the thickness of micrometer-sized collagen matrices.

Graphical abstract: The construction of cell-density controlled three-dimensional tissues by coating micrometer-sized collagen fiber matrices on single cell surfaces

Supplementary files

Article information

Article type
Communication
Submitted
22 Aug 2014
Accepted
12 Sep 2014
First published
15 Sep 2014

RSC Adv., 2014,4, 46141-46144

Author version available

The construction of cell-density controlled three-dimensional tissues by coating micrometer-sized collagen fiber matrices on single cell surfaces

C. Liu, M. Matsusaki and M. Akashi, RSC Adv., 2014, 4, 46141 DOI: 10.1039/C4RA09085C

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