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Issue 99, 2014
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45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

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Abstract

Highly porous 45S5 bioactive glass-based scaffolds prepared by foam replication method were coated with cellulose nanowhiskers by dip coating method. The obtained cellulose nanowhisker-coated scaffolds retained the high porosity and interconnected pore structure. The cellulose coating improved the mechanical properties of the scaffolds and did not hinder their bioactivity in simulated body fluid. In vitro biocompatibility assessment was carried out by qualitative evaluation of the morphology of osteoblast-like cells (MG-63) seeded onto the scaffolds. The cells were shown to attach and spread on both uncoated scaffolds and cellulose nanowhisker-coated scaffolds, thus cellulose nanowhisker coating seems to have no negative influence on the behavior of MG-63 cells. The obtained bioactive and biocompatible composite scaffolds represent promising candidates for bone tissue engineering applications.

Graphical abstract: 45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

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Publication details

The article was received on 28 Jul 2014, accepted on 10 Oct 2014 and first published on 10 Oct 2014


Article type: Paper
DOI: 10.1039/C4RA07740G
Citation: RSC Adv., 2014,4, 56156-56164
  • Open access: Creative Commons BY license
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    45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

    W. Li, N. Garmendia, U. Pérez de Larraya, Y. Ding, R. Detsch, A. Grünewald, J. A. Roether, D. W. Schubert and A. R. Boccaccini, RSC Adv., 2014, 4, 56156
    DOI: 10.1039/C4RA07740G

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