An efficient method for the synthesis of heteroaryl C–O bonds in the absence of added transition metal catalysts

Abstract

Reaction of 2-chloropyrazine and 2-chloropyrimidine with phenols and alcohols in the presence of K₂CO₃ in DMSO results in high yielding S_NAr coupling. The reaction works particularly well with phenols and yields are comparable or superior to the metal-catalysed couplings described in the literature.