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Issue 49, 2014
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In vitro osteogenesis of mesenchymal stem cells promoted by the release of La3+ and SiO44− from sheet-shaped lanthanum dropped hexagonal mesoporous silicon

Weikang Xu,abc  Liyan Wang,abc  Kun Wei,*abc  You Lingabc  and  Shizhen Zhongabc 
Author affiliations

* Corresponding authors

a School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: weikun@scut.edu.cn
Tel: +86 20 39380 098

b National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China

c Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China

Abstract

In this study, in vitro osteogenesis was successfully promoted in mouse mesenchymal stem cells (BMSCs) by the release of La3+ and SiO44− from a sheet-shaped lanthanum dropped hexagonal mesoporous silica (La-HMS). In comparison with previous nano-sphere shaped La-HMS, the sheet-shaped morphology was similar to the inorganic component of bone, which could provide better toughness during bone repair and regeneration. The successful incorporation of La3+ into the HMS was confirmed by the results of XRD and ICP-AES. In vitro proliferation was verified by CCK-8 and osteogenesis was verified by an alkaline phosphatase (ALP) activity assay, ALP staining, a calcium secretion assay and collagen secretion analysis. Considering the renewable source and highly proliferative nature of BMSCs, the achievement of engineered BMSC osteogenesis with this La-HMS could allow new applications in major bone repair and regeneration.

Graphical abstract: In vitro osteogenesis of mesenchymal stem cells promoted by the release of La3+ and SiO44− from sheet-shaped lanthanum dropped hexagonal mesoporous silicon

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Publication details

The article was received on 03 Apr 2014, accepted on 30 Apr 2014 and first published on 30 Apr 2014


Article type: Paper
DOI: 10.1039/C4RA02987A
Citation: RSC Adv., 2014,4, 25948-25956
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    In vitro osteogenesis of mesenchymal stem cells promoted by the release of La3+ and SiO44− from sheet-shaped lanthanum dropped hexagonal mesoporous silicon

    W. Xu, L. Wang, K. Wei, Y. Ling and S. Zhong, RSC Adv., 2014, 4, 25948
    DOI: 10.1039/C4RA02987A

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