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Issue 44, 2014
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Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

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Abstract

A novel and efficient method for the selective monobenzoylation of N-Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc)2 and Cs2CO3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the monobenzoylation of 1,3-diols.

Graphical abstract: Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

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Publication details

The article was received on 21 Mar 2014, accepted on 12 May 2014 and first published on 13 May 2014


Article type: Paper
DOI: 10.1039/C4RA02401J
Citation: RSC Adv., 2014,4, 23131-23136
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    Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

    H. Hikawa, M. Hamada, Y. Yokoyama and I. Azumaya, RSC Adv., 2014, 4, 23131
    DOI: 10.1039/C4RA02401J

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