Issue 44, 2014
From the journal:

RSC Advances

Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720†

Hidemasa Hikawa,*a   Maiko Hamada,a   Yuusaku Yokoyama*a  and  Isao Azumayaa  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
E-mail: hidemasa.hikawa@phar.toho-u.ac.jp, yokoyama@phar.toho-u.ac.jp

Abstract

A novel and efficient method for the selective monobenzoylation of N-Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc)2 and Cs2CO3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the monobenzoylation of 1,3-diols.

Graphical abstract: Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

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Article information

DOI
https://doi.org/10.1039/C4RA02401J
Article type
Paper
Submitted
21 Mar 2014
Accepted
12 May 2014
First published
13 May 2014

RSC Adv., 2014,4, 23131-23136

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Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

H. Hikawa, M. Hamada, Y. Yokoyama and I. Azumaya, RSC Adv., 2014, 4, 23131 DOI: 10.1039/C4RA02401J

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