Issue 55, 2014

Fabrication of degradable polymer microspheres via pH-responsive chitosan-based Pickering emulsion photopolymerization

Abstract

Pickering emulsion stabilized by pH-reversible chitosan is developed to prepare degradable polymer microspheres by emulsion photopolymerization, where chitosan acts as a green and recyclable particulate emulsifier. The thiol–ene photopolymerization of trimethylolpropane tris(3-mercaptopropionate) and trimethylolpropane triacrylate is initiated by UV irradiation. Chitosan adsorbed at the surface of the microspheres can be recycled for polymerization at least three times. Moreover, ibuprofen (IBU) is loaded into the microspheres. The higher the release temperature or pH value, the faster release rate and higher release extent of IBU from the microspheres are found. Meanwhile, the resulting microspheres exhibit a good degradability in 1 M NaOH aqueous solution, with a weight loss of about 90 wt% after 35 days. This study demonstrates a potential green and recyclable application of chitosan in fabrication of degradable polymer microspheres.

Graphical abstract: Fabrication of degradable polymer microspheres via pH-responsive chitosan-based Pickering emulsion photopolymerization

Supplementary files

Article information

Article type
Paper
Submitted
25 Feb 2014
Accepted
04 Jun 2014
First published
09 Jun 2014

RSC Adv., 2014,4, 29344-29351

Author version available

Fabrication of degradable polymer microspheres via pH-responsive chitosan-based Pickering emulsion photopolymerization

H. Liu, Z. Wei, M. Hu, Y. Deng, Z. Tong and C. Wang, RSC Adv., 2014, 4, 29344 DOI: 10.1039/C4RA01660B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements