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Issue 19, 2014
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Palladium catalyzed novel monoarylation and symmetrical/unsymmetrical diarylation of imidazo[1,2-a]pyrazines and their in vitro anticancer activities

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Abstract

Palladium catalyzed Suzuki–Miyaura cross-coupling reactions are reported for the synthesis of monoarylated (at the C8 position) and symmetrical diarylated (at the C6 and C8 positions) imidazo[1,2-a]pyrazines. Monoarylated products have also been used to synthesize unsymmetrical C6/C8 diarylated products. These compounds were screened for in vitro antitumor activities against a preliminary tumor cell line panel assay.

Graphical abstract: Palladium catalyzed novel monoarylation and symmetrical/unsymmetrical diarylation of imidazo[1,2-a]pyrazines and their in vitro anticancer activities

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Publication details

The article was received on 02 Dec 2013, accepted on 18 Dec 2013 and first published on 19 Dec 2013


Article type: Communication
DOI: 10.1039/C3RA47192F
Citation: RSC Adv., 2014,4, 9885-9892
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    Palladium catalyzed novel monoarylation and symmetrical/unsymmetrical diarylation of imidazo[1,2-a]pyrazines and their in vitro anticancer activities

    R. Goel, V. Luxami and K. Paul, RSC Adv., 2014, 4, 9885
    DOI: 10.1039/C3RA47192F

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