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Issue 19, 2014
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Imine-linked chemosensors for the detection of Zn2+ in biological samples

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Abstract

A chemosensor 1 with a long hydrocarbon chain and polar end group is synthesized by the simple condensation reaction of a long chain amine with salicylaldehyde. A long chain hydrocarbon with a polar end group is used because of its solubility in an aqueous surfactant solution, which ensures that it can be used in a neutral water medium. The rationale for choosing an aryl aldehyde with –OH functionality is based upon the fact that a chelate ring consisting of an –OH group and an sp2 nitrogen donor is always better for the selective recognition of Zn2+. The sensor shows selective binding to Zn2+ in 1% Triton-X-100 solution. Binding of Zn2+ by sensor 3 leads to an approximately 300% enhancement in the fluorescence intensity of the sensor, due to the combined effects of excited state intramolecular proton transfer (ESIPT) and the inhibition of the photo-induced electron transfer (PET) process by the –OH group. The fluorescence emission profiles of sensor 1 show some changes in the low and high pH ranges, however the sensor remains stable in the pH range 4–9, which makes it appropriate for use in biological fluids.

Graphical abstract: Imine-linked chemosensors for the detection of Zn2+ in biological samples

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Publication details

The article was received on 16 Nov 2013, accepted on 13 Dec 2013 and first published on 16 Dec 2013


Article type: Paper
DOI: 10.1039/C3RA46759G
Citation: RSC Adv., 2014,4, 9784-9790
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    Imine-linked chemosensors for the detection of Zn2+ in biological samples

    P. Saluja, V. K. Bhardwaj, T. Pandiyan, S. Kaur, N. Kaur and N. Singh, RSC Adv., 2014, 4, 9784
    DOI: 10.1039/C3RA46759G

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