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Issue 23, 2014
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Self-assembled monolayer for AFM measurements of Tobacco Mosaic Virus (TMV) at the atomic level

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Abstract

Biosensors are based on the conversion of a biological response to an electrical signal. One of the major challenges is to ascertain that the receptor is not denatured when immobilised (covalently or not) on the device. In this work, a protein receptor (virus) was immobilised on two different surfaces, mica and self-assembled monolayer (SAM), and its height was determined by atomic force microscopy measurements at the atomic level. Results clearly showed that expected dimensions of Tobacco Mosaic Virus (TMV) are obtained after immobilisation onto a soft organic SAM.

Graphical abstract: Self-assembled monolayer for AFM measurements of Tobacco Mosaic Virus (TMV) at the atomic level

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Publication details

The article was received on 15 Nov 2013, accepted on 17 Feb 2014 and first published on 17 Feb 2014


Article type: Communication
DOI: 10.1039/C3RA46716C
Citation: RSC Adv., 2014,4, 11927-11930
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    Self-assembled monolayer for AFM measurements of Tobacco Mosaic Virus (TMV) at the atomic level

    M. Meillan, M. A. Ramin, T. Buffeteau, S. Marsaudon, M. Odorico, S. W. Chen, J. Pellequer, M. Degueil, K. Heuzé, L. Vellutini and B. Bennetau, RSC Adv., 2014, 4, 11927
    DOI: 10.1039/C3RA46716C

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