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Issue 95, 2014
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Concise and stereoselective synthesis of (±)-Hagen's gland lactone

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Abstract

The synthesis of (±)-Hagen's gland lactone 1 has been completed in three steps in 44% from commercially available starting materials. The work is highlighted by a straightforward preparation of butenolide through an epoxide opening using 2-lithiofuran and a concise and stereoselective synthesis of furano-γ-lactone by a novel DBU-promoted sequential isomerization/intramolecular oxa-Michael addition of a hydroxybutenolide.

Graphical abstract: Concise and stereoselective synthesis of (±)-Hagen's gland lactone

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Publication details

The article was received on 30 Aug 2014, accepted on 10 Oct 2014 and first published on 13 Oct 2014


Article type: Communication
DOI: 10.1039/C4RA11763H
Citation: RSC Adv., 2014,4, 52637-52639
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    Concise and stereoselective synthesis of (±)-Hagen's gland lactone

    D. Lee, I. Shin, Y. Hwang, K. Lee, S. Seo and H. Kim, RSC Adv., 2014, 4, 52637
    DOI: 10.1039/C4RA11763H

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