Syntheses of indolizinones from an intramolecular one-pot process of gem-dibromoolefins

Abstract

Transition-metal-catalyzed C–H activation has recently emerged as a powerful tool for the syntheses of natural products and bioactive compounds. We developed an efficient sequential one-pot intramolecular C–N bond formation and direct C–H arylation method to construct a series of unusual indolizinone scaffolds using gem-dibromoolefins in moderate to good yields under mild conditions.