Issue 91, 2014
From the journal:

RSC Advances

Synthesis of β-ketoesters from renewable resources and Meldrum's acid†

Rafael C. Brinkerhoff,a   Hernan F. Tarazona,a   Patrick M. de Oliveira,a   Darlene C. Flores,a   Caroline Da R. Montes D'Oca,b   Dennis Russowskyb  and  Marcelo G. Montes D'Oca*a  

* Corresponding authors

a Universidade Federal do Rio Grande, Laboratório Kolbe de Síntese Orgânica, Rio Grande-RS, Brazil
E-mail: dqmdoca@furg.br
Tel: +55 5332336964

b Universidade Federal do Rio Grande do Sul-UFRGS, Laboratório de Síntese Orgânica, Porto Alegre-RS, Brazil

Abstract

β-Ketoesters are valuable building blocks for the synthesis of compounds with different biological activities. In this study, a series of fatty β-ketoesters were obtained from fatty acids and Meldrum's acid using N,N-dicyclohexylcarbodiimide and dimethylaminopyridine. In addition, we demonstrate for the first time the synthesis of new fatty β-ketoesters from oleic (cis-C18:1), elaidic (trans-C18:1), ricinoleic (cis-C18:1, 12-OH), linoleic (cis,cis-C18:2), and linolenic (cis,cis,cis-C18:3) acids in good yields.

Graphical abstract: Synthesis of β-ketoesters from renewable resources and Meldrum's acid

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Article information

DOI
https://doi.org/10.1039/C4RA08986C
Article type
Communication
Submitted
20 Aug 2014
Accepted
18 Sep 2014
First published
23 Sep 2014

RSC Adv., 2014,4, 49556-49559

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Synthesis of β-ketoesters from renewable resources and Meldrum's acid

R. C. Brinkerhoff, H. F. Tarazona, P. M. de Oliveira, D. C. Flores, C. D. R. Montes D'Oca, D. Russowsky and M. G. Montes D'Oca, RSC Adv., 2014, 4, 49556 DOI: 10.1039/C4RA08986C

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