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Issue 96, 2014
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Gold nanorods for optimized photothermal therapy: the influence of irradiating in the first and second biological windows

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Abstract

The light-to-heat conversion efficiency of gold nanorods (GNRs) with surface plasmon resonances in the first (700–950 nm) and second (1000–1350 nm) biological windows has been studied by Quantum Dot based Fluorescence Nanothermometry. It has been found that red-shifting the GNR longitudinal surface plasmon resonance wavelength (λSPR) from the first to the second biological window is accompanied by a remarkable (close to 40%) reduction in their heating efficiency. Based on numerical simulations, we have concluded that this lower heating efficiency is caused by a reduction in the absorption efficiency (ratio between absorption and extinction cross sections). Thermal stability and ex vivo experiments have corroborated that GNRs with λSPR at around 800 nm seem to be especially suitable for efficient photothermal therapies with minimum collateral effects.

Graphical abstract: Gold nanorods for optimized photothermal therapy: the influence of irradiating in the first and second biological windows

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The article was received on 20 Aug 2014, accepted on 10 Oct 2014 and first published on 10 Oct 2014


Article type: Paper
DOI: 10.1039/C4RA08956A
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Citation: RSC Adv., 2014,4, 54122-54129
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    Gold nanorods for optimized photothermal therapy: the influence of irradiating in the first and second biological windows

    L. M. Maestro, E. Camarillo, J. A. Sánchez-Gil, R. Rodríguez-Oliveros, J. Ramiro-Bargueño, A. J. Caamaño, F. Jaque, J. G. Solé and D. Jaque, RSC Adv., 2014, 4, 54122
    DOI: 10.1039/C4RA08956A

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