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Issue 74, 2014
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Transition metal-catalyzed redox isomerization of codeine and morphine in water

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Abstract

A water-soluble rhodium complex formed from commercially available [Rh(COD)(CH3CN)2]BF4 and 1,3,5-triaza-7-phosphaadamantane (PTA) catalyzes the isomerization of both codeine and morphine into hydrocodone and hydromorphone with very high efficiency. The reaction is performed in water, allowing isolation of the final products by simple filtration, which results in very high isolated yields. The reactions can be easily scaled up to 100 g.

Graphical abstract: Transition metal-catalyzed redox isomerization of codeine and morphine in water

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The article was received on 28 Jul 2014, accepted on 06 Aug 2014 and first published on 06 Aug 2014


Article type: Paper
DOI: 10.1039/C4RA07735K
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Citation: RSC Adv., 2014,4, 39519-39522
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    Transition metal-catalyzed redox isomerization of codeine and morphine in water

    A. B. Gómez, P. Holmberg, Jan-E. Bäckvall and B. Martín-Matute, RSC Adv., 2014, 4, 39519
    DOI: 10.1039/C4RA07735K

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