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Issue 64, 2014
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Enantioselective transesterification of (R,S)-2-pentanol catalyzed by a new flower-like nanobioreactor

Zhuofu Wu,ab  Xiang Li,c  Fuguang Li,d  Hong Yue,a  Chengyan He,b  Feng Xie*b  and  Zhi Wang*a 
Author affiliations

* Corresponding authors

a Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Sciences, Jilin University, Changchun 130012, P. R.China
E-mail: wangzhi@jlu.edu.cn
Fax: +86-431-88980440
Tel: +86-431-85155243

b The Third Hospital of Jilin University, Changchun 130021, P. R. China
E-mail: xiefeng11@126.com
Fax: +86-431-84995455
Tel: +86-431-84995455

c State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China

d The First Hospital of Jilin University, Changchun 130021, P. R. China

Abstract

The lipase-incorporated nanoflower was prepared and used for resolution of (R,S)-2-pentanol with vinyl acetate as an acyl donor in organic solvents. SEM images indicated that the lipase-incorporated nanoflower had high surface area which was favourable for mass transfer. The FTIR spectrum identified the presence of the lipase in the nanoflower. The lipase-incorporated nanoflower could display its maximum enzyme activity (22.5 μmol h−1 mg−1) and good enantioselectivity (E value, 47.3) under the optimal reaction conditions (in cyclohexane at 60 °C and water activity of 0.10). After ten continuous batches, the nanoflower retained 98.7% of the initial enzyme activity and 95.6% of the initial enantioselectivity.

Graphical abstract: Enantioselective transesterification of (R,S)-2-pentanol catalyzed by a new flower-like nanobioreactor

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Publication details

The article was received on 12 May 2014, accepted on 29 Jul 2014 and first published on 30 Jul 2014


Article type: Paper
DOI: 10.1039/C4RA04431B
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2014,4, 33998-34002
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    Enantioselective transesterification of (R,S)-2-pentanol catalyzed by a new flower-like nanobioreactor

    Z. Wu, X. Li, F. Li, H. Yue, C. He, F. Xie and Z. Wang, RSC Adv., 2014, 4, 33998
    DOI: 10.1039/C4RA04431B

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