Issue 39, 2014

Cationic and anionic reverse micelles as the molecular crowding container for G-quadruplex structure

Abstract

In this study, we tested the feasibility of using reverse micelles (RMs) as molecular crowding containers for DNA G-quadruplex. The results suggest that the RMs formed by anionic surfactants should be avoided for the molecular crowding studies of G-quadruplex structures. In contrast to the molecular crowding condition created by polyethylene glycol, the human telomeric sequence d[AG3(T2AG3)3] shows different conformations and drug binding stoichiometry in cationic RMs. Cationic RMs allow the DNA to avoid the dehydration effect caused by polyethylene glycol, and are therefore ideal containers for molecular crowding studies.

Graphical abstract: Cationic and anionic reverse micelles as the molecular crowding container for G-quadruplex structure

Supplementary files

Article information

Article type
Communication
Submitted
11 Mar 2014
Accepted
11 Apr 2014
First published
14 Apr 2014

RSC Adv., 2014,4, 20531-20534

Author version available

Cationic and anionic reverse micelles as the molecular crowding container for G-quadruplex structure

M. Ho and C. Chang, RSC Adv., 2014, 4, 20531 DOI: 10.1039/C4RA02141J

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