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Issue 28, 2014
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Bioactive norditerpenoids from Flickingeria fimbriata

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Abstract

Seven new degraded diterpenoids (1–6 and 11), four new ent-pimarane type diterpenoids (7–10) and a known analogue (12) were isolated from the stem of Flickingeria fimbriata. Compounds 1–4, namely norflickinflimiods A–D, possessed a rare 16-nor-ent-pimarane skeleton, and 5–6, namely norflickinflimiods E and F, represented an unusual skeleton of 15,16-dinor-ent-pimarane. The structures including the absolute configurations of 1–12 were elucidated using spectroscopic analysis, single-crystal X-ray diffraction, computational methods, and chemical correlations. All the isolates were screened for anti-inflammatory and antitumor activities, and compounds 5, 6, 9, and 12 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced TNF-α production in RAW264.7 cells with IC50 values less than 10 μM, while compounds 8–11 exhibited cytotoxicity against MCF-7 cells (9.6, 9.0, 12.0, and 15.6 μM).

Graphical abstract: Bioactive norditerpenoids from Flickingeria fimbriata

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Publication details

The article was received on 29 Jan 2014, accepted on 07 Mar 2014 and first published on 11 Mar 2014


Article type: Paper
DOI: 10.1039/C4RA00835A
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Citation: RSC Adv., 2014,4, 14447-14456
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    Bioactive norditerpenoids from Flickingeria fimbriata

    J. Chen, Z. Zhao, X. Xue, G. Tang, L. Zhu, D. Yang and L. Jiang, RSC Adv., 2014, 4, 14447
    DOI: 10.1039/C4RA00835A

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