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Issue 7, 2014
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H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis

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Abstract

Glycosylation of nucleobases is achieved by heating metal free aqueous solution of nucleobase and sugar. It seems that abstraction of N9/N1 H by C1′-OH promotes N9/N1(nucleobase)-C1′ (sugar) covalent bond formation.

Graphical abstract: H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis

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Publication details

The article was received on 30 Aug 2013, accepted on 26 Nov 2013 and first published on 27 Nov 2013


Article type: Communication
DOI: 10.1039/C3RA44776F
Citation: RSC Adv., 2014,4, 3158-3161
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    H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis

    P. Singh, A. Singh, J. Kaur and W. Holzer, RSC Adv., 2014, 4, 3158
    DOI: 10.1039/C3RA44776F

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