Jump to main content
Jump to site search

Issue 9, 2014
Previous Article Next Article

Microfluidic laboratories for C. elegans enhance fundamental studies in biology

Author affiliations

Abstract

The in vivo analysis of a small multicellular organism such as the nematode Caenorhabditis elegans, enables fundamental biomedical and environmental studies of a complete organism under normal physiological conditions. Continuous advancements in photonics, electronics, as well as the material sciences, are paving the way towards miniaturized bioanalytical systems, known as labs-on-a-chip (LOC). These microfluidic technologies facilitate the manipulation and study of nematodes in a precise, real-time, portable, and cost-effective manner, potentially for high throughput operation. In this paper we review all currently available “worm-on-a-chip” miniaturized systems that address the manipulation, detection, and study of the sensory response of C. elegans, and take a close look at their advantages, application challenges, and scientific potential. The paper aims to consolidate recent results of dedicated worm microsystems that target a better understanding of C. elegans.

Graphical abstract: Microfluidic laboratories for C. elegans enhance fundamental studies in biology

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Oct 2013, accepted on 25 Nov 2013 and first published on 27 Nov 2013


Article type: Review Article
DOI: 10.1039/C3RA43758B
Citation: RSC Adv., 2014,4, 4691-4709
  •   Request permissions

    Microfluidic laboratories for C. elegans enhance fundamental studies in biology

    N. A. Bakhtina and J. G. Korvink, RSC Adv., 2014, 4, 4691
    DOI: 10.1039/C3RA43758B

Search articles by author

Spotlight

Advertisements