Room temperature, open-flask C–H arylation of electron-deficient heteroarenes with triazenes: rapid synthesis of heterobiaryls

Abstract

Aryl triazenes, a source of aryl radicals, were coupled with heteroarenes via C–H functionalization to produce heterobiaryls in moderate to good yields. Couplings proceeded under an open atmosphere at ambient temperature for 3–24 h. Best results were obtained with electron-deficient heteroarenes, while both electron donating and withdrawing substituents in the triazene moieties were tolerated.