Issue 9, 2014
From the journal:

Organic Chemistry Frontiers

Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium-catalyzed amino and oxyacetoxylation†‡

A. D. Manick,a   G. Duret,a   D. N. Tran,a   F. Berhal*a  and  G. Prestat*a  

* Corresponding authors

a Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Université Paris Descartes, 45 rue des Saints Pères, 75006 Paris, France
E-mail: farouk.berhal@parisdescartes.fr, guillaume.prestat@parisdescartes.fr

Abstract

Palladium-catalyzed amino and oxyacetoxylation have been developed to furnish 1,4-benzodiazepinones and 1,4-benzoxazepinones through the diheterofunctionalization of alkenes. This study demonstrates the ability of this new methodology to allow 7-exo ring-closure.

Graphical abstract: Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium-catalyzed amino and oxyacetoxylation

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Article information

DOI
https://doi.org/10.1039/C4QO00179F
Article type
Research Article
Submitted
27 Jun 2014
Accepted
19 Aug 2014
First published
20 Aug 2014

Org. Chem. Front., 2014,1, 1058-1061

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Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium-catalyzed amino and oxyacetoxylation

A. D. Manick, G. Duret, D. N. Tran, F. Berhal and G. Prestat, Org. Chem. Front., 2014, 1, 1058 DOI: 10.1039/C4QO00179F

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