Issue 6, 2014

Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP

Abstract

In this paper we compare and contrast three approaches for labelling polymers with functional groups via ring-opening metathesis polymerization (ROMP). We explored the incorporation of functionality via initiation, termination and propagation employing an array of novel initiators, termination agents and monomers. The goal was to allow the generation of selectively labelled and well-defined polymers that would in turn lead to the formation of labelled nanomaterials. Norbornene analogues, prepared as functionalized monomers for ROMP, included fluorescent dyes (rhodamine, fluorescein, EDANS, and coumarin), quenchers (DABCYL), conjugatable moieties (NHS esters, pentafluorophenyl esters), and protected amines. In addition, a set of symmetrical olefins for terminally labelling polymers, and for the generation of initiators in situ is described.

Graphical abstract: Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP

Supplementary files

Article information

Article type
Paper
Submitted
24 Sep 2013
Accepted
13 Nov 2013
First published
10 Dec 2013

Polym. Chem., 2014,5, 1954-1964

Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP

M. P. Thompson, L. M. Randolph, C. R. James, A. N. Davalos, M. E. Hahn and N. C. Gianneschi, Polym. Chem., 2014, 5, 1954 DOI: 10.1039/C3PY01338C

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