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Issue 6, 2014
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Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP

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Abstract

In this paper we compare and contrast three approaches for labelling polymers with functional groups via ring-opening metathesis polymerization (ROMP). We explored the incorporation of functionality via initiation, termination and propagation employing an array of novel initiators, termination agents and monomers. The goal was to allow the generation of selectively labelled and well-defined polymers that would in turn lead to the formation of labelled nanomaterials. Norbornene analogues, prepared as functionalized monomers for ROMP, included fluorescent dyes (rhodamine, fluorescein, EDANS, and coumarin), quenchers (DABCYL), conjugatable moieties (NHS esters, pentafluorophenyl esters), and protected amines. In addition, a set of symmetrical olefins for terminally labelling polymers, and for the generation of initiators in situ is described.

Graphical abstract: Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP

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Publication details

The article was received on 24 Sep 2013, accepted on 13 Nov 2013 and first published on 10 Dec 2013


Article type: Paper
DOI: 10.1039/C3PY01338C
Citation: Polym. Chem., 2014,5, 1954-1964
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    Labelling polymers and micellar nanoparticles via initiation, propagation and termination with ROMP

    M. P. Thompson, L. M. Randolph, C. R. James, A. N. Davalos, M. E. Hahn and N. C. Gianneschi, Polym. Chem., 2014, 5, 1954
    DOI: 10.1039/C3PY01338C

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