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Issue 3, 2014
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Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation

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Abstract

Grp1-associated scaffold protein (Grasp), the product of a retinoic acid-induced gene in P19 embryonal carcinoma cells, is expressed primarily in brain, heart, and lung of the mouse. We report herein that Grasp transcripts are also found in mouse skin in which the Grasp gene is robustly induced following acute ultraviolet-B (UVB) exposure. Grasp−/− mice were found to exhibit delayed epidermal proliferation and a blunted apoptotic response after acute UVB exposure. Immunohistochemical analyses revealed that the nuclear residence time of the tumor suppressor protein p53 was reduced in Grasp−/− mice after UVB exposure. Taken together, our results suggest that a physiological role of Grasp may be to regulate skin homeostasis after UVB exposure, potentially by influencing p53-mediated apoptotic responses in skin.

Graphical abstract: Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation

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Publication details

The article was received on 07 Oct 2013, accepted on 23 Dec 2013 and first published on 06 Jan 2014


Article type: Paper
DOI: 10.1039/C3PP50351H
Citation: Photochem. Photobiol. Sci., 2014,13, 531-540
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    Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation

    A. Venkataraman, D. J. Coleman, D. J. Nevrivy, T. Long, C. Kioussi, A. K. Indra and M. Leid, Photochem. Photobiol. Sci., 2014, 13, 531
    DOI: 10.1039/C3PP50351H

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