An example of the subtle interplay between the intended templation and a very fast reequilibration of a dynamic combinatorial library of imines that occurs upon a solvent change is reported. Such seemingly “irrelevant” details of the procedure like imine dissolution time prior to reduction may dictate the outcome of the whole reaction.
K. Ziach, A. Kulesza and J. Jurczak, Org. Biomol. Chem., 2014, 12, 3827 DOI: 10.1039/C4OB00507D
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