Jump to main content
Jump to site search

Issue 26, 2014
Previous Article Next Article

RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

Author affiliations

Abstract

Here we report an efficient method for the synthesis of RNA–peptide conjugates by inverse-electron demand Diels–Alder reaction. Various dienophiles were enzymatically incorporated into RNA and reacted with a chemically synthesized diene-modified peptide. The Diels–Alder reaction proceeds with near-quantitative yields in aqueous solution with stoichiometric amounts of reactants, even at low micromolar concentrations.

Graphical abstract: RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jan 2014, accepted on 20 May 2014 and first published on 20 May 2014


Article type: Paper
DOI: 10.1039/C4OB00076E
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 4701-4707
  •   Request permissions

    RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

    S. Ameta, J. Becker and A. Jäschke, Org. Biomol. Chem., 2014, 12, 4701
    DOI: 10.1039/C4OB00076E

Search articles by author

Spotlight

Advertisements