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Issue 12, 2014
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Base mediated synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes in water

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Abstract

An environmentally friendly and mild procedure to obtain 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes has been developed. The reactions took place in water with inorganic base (K3PO4) as the only promoter. Various desired products have been prepared in moderate to good yields under identical conditions. Further transformation of dihydroquinazolinones to quinazolinones was carried out as well with TBHP as the oxidant.

Graphical abstract: Base mediated synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes in water

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Publication details

The article was received on 05 Dec 2013, accepted on 23 Jan 2014 and first published on 23 Jan 2014


Article type: Communication
DOI: 10.1039/C3OB42434K
Citation: Org. Biomol. Chem., 2014,12, 1865-1870
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    Base mediated synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes in water

    X. Wu, S. Oschatz, A. Block, A. Spannenberg and P. Langer, Org. Biomol. Chem., 2014, 12, 1865
    DOI: 10.1039/C3OB42434K

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