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Issue 11, 2014
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Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells

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Abstract

The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.

Graphical abstract: Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells

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Publication details

The article was received on 18 Oct 2013, accepted on 13 Jan 2014 and first published on 14 Jan 2014


Article type: Paper
DOI: 10.1039/C3OB42082E
Citation: Org. Biomol. Chem., 2014,12, 1804-1811
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    Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells

    P. M. R. Pereira, J. J. Carvalho, S. Silva, J. A. S. Cavaleiro, R. J. Schneider, R. Fernandes and J. P. C. Tomé, Org. Biomol. Chem., 2014, 12, 1804
    DOI: 10.1039/C3OB42082E

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