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Issue 42, 2014
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Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides

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Abstract

A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere.

Graphical abstract: Direct synthesis of polysubstituted 2-aminothiophenes by Cu(ii)-catalyzed addition/oxidative cyclization of alkynoates with thioamides

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Publication details

The article was received on 21 Jul 2014, accepted on 29 Aug 2014 and first published on 01 Sep 2014


Article type: Paper
DOI: 10.1039/C4OB01534G
Citation: Org. Biomol. Chem., 2014,12, 8473-8479
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    Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides

    L. Ge, Z. Wang, X. An, X. Luo and W. Deng, Org. Biomol. Chem., 2014, 12, 8473
    DOI: 10.1039/C4OB01534G

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