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Issue 39, 2014
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Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C

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Abstract

The total synthesis of desmethylabyssomicin C analogue 1 was accomplished using diastereotopos-selective ring closing metathesis and Nozaki–Hiyama–Kishi cyclization as the key steps. The synthetic analogue retained its antibacterial activity against methicillin-resistant S. aureus strains, whereas its cytotoxicity decreased for three orders of magnitude, as compared to atrop-abyssomicin C.

Graphical abstract: Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C

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Publication details

The article was received on 09 Jul 2014, accepted on 14 Aug 2014 and first published on 14 Aug 2014


Article type: Communication
DOI: 10.1039/C4OB01436G
Citation: Org. Biomol. Chem., 2014,12, 7682-7685
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    Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C

    R. Matovic, F. Bihelovic, M. Gruden-Pavlovic and R. N. Saicic, Org. Biomol. Chem., 2014, 12, 7682
    DOI: 10.1039/C4OB01436G

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