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Issue 41, 2014
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A small synthetic molecule forms selective potassium channels to regulate cell membrane potential and blood vessel tone

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Abstract

In living cell membranes, K+ permeability is higher than that of other ions such as Na+ and Cl owing to abundantly expressed K+ channels. Polarized membrane potential is mainly established by K+ outward flow because the K+ concentration in the intracellular side is much higher than that in the extracellular side. We have found that the small synthetic molecule 1 is capable of self-assembling into selective K+ channels, enhancing K+ permeability and hyperpolarizing liposome membrane potential. Interestingly, molecule 1 also functions as K+ channel hyperpolarizing living cell membrane potential and relaxing agonist-induced blood vessel contraction. Therefore, it may have the potential to become a lead compound for the treatment of human diseases associated with K+ channel dysfunction.

Graphical abstract: A small synthetic molecule forms selective potassium channels to regulate cell membrane potential and blood vessel tone

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Publication details

The article was received on 08 Jul 2014, accepted on 14 Aug 2014 and first published on 14 Aug 2014


Article type: Paper
DOI: 10.1039/C4OB01420K
Citation: Org. Biomol. Chem., 2014,12, 8174-8179
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    A small synthetic molecule forms selective potassium channels to regulate cell membrane potential and blood vessel tone

    H. Zha, B. Shen, K. Yau, S. Li, X. Yao and D. Yang, Org. Biomol. Chem., 2014, 12, 8174
    DOI: 10.1039/C4OB01420K

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