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Issue 41, 2014
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Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3

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Abstract

We report here the syntheses of mono- to tetravalent glycoclusters containing 1-methylene-C-β-lactose. The 1-methylene-C-β-lactose moiety has been synthesized from octa-acetyl-β-lactose using the key carbonyl insertion reaction and linked to a series of alkynlated scaffolds via CuAAC reaction to afford mono- to tetravalent glycoclusters. The binding affinities of the final products to galectin-3 were found in the range of 10–100 μM.

Graphical abstract: Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3

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Publication details

The article was received on 02 Jul 2014, accepted on 13 Aug 2014 and first published on 14 Aug 2014


Article type: Paper
DOI: 10.1039/C4OB01374C
Citation: Org. Biomol. Chem., 2014,12, 8180-8195
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    Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3

    W. Yao, M. Xia, X. Meng, Q. Li and Z. Li, Org. Biomol. Chem., 2014, 12, 8180
    DOI: 10.1039/C4OB01374C

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