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Issue 40, 2014
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Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18F-labeling

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Abstract

A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution with [18F]fluoride is described. Different radiolabeled aliphatic and aromatic compounds were prepared in high radiochemical yields simply by heating of quaternary anilinium, diaryliodonium and triarylsulfonium [18F]fluorides in suitable solvents. The latter were obtained via direct elution of 18F− from an anion exchange resin with alcoholic solutions of onium precursors. Neither azeotropic evaporation of water, nor a base, nor any other additives like cryptands or crown ethers were necessary. Due to its simplicity this method should be highly suitable for automated radiosyntheses, especially in microfluidic devices.

Graphical abstract: Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18F-labeling

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Publication details

The article was received on 30 Jun 2014, accepted on 15 Aug 2014 and first published on 18 Aug 2014


Article type: Paper
DOI: 10.1039/C4OB01336K
Citation: Org. Biomol. Chem., 2014,12, 8094-8099
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    Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18F-labeling

    R. Richarz, P. Krapf, F. Zarrad, E. A. Urusova, B. Neumaier and B. D. Zlatopolskiy, Org. Biomol. Chem., 2014, 12, 8094
    DOI: 10.1039/C4OB01336K

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