Jump to main content
Jump to site search

Issue 39, 2014
Previous Article Next Article

Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy

Author affiliations

Abstract

The palladium catalytic system was first applied to 2-arylquinazoline synthesis via hydrogen transfer methodology. Various (E)-2-nitrobenzaldehyde O-methyl oximes reacted easily with alcohols or benzyl amines to provide N-heterocyclic compounds in good to high yields. Similarly, the heterocyclic products could be prepared by the reaction of 1-(2-nitrophenyl)ethanone, urea and benzyl alcohols. In these reactions, the nitro group was reduced in situ by hydrogen generated from the alcohol dehydrogenation step.

Graphical abstract: Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jun 2014, accepted on 06 Aug 2014 and first published on 06 Aug 2014


Article type: Paper
DOI: 10.1039/C4OB01296H
Citation: Org. Biomol. Chem., 2014,12, 7792-7799
  •   Request permissions

    Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy

    H. Wang, H. Chen, Y. Chen and G. Deng, Org. Biomol. Chem., 2014, 12, 7792
    DOI: 10.1039/C4OB01296H

Search articles by author

Spotlight

Advertisements