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A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques

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a
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: khanaoka@mol.f.u-tokyo.ac.jp;
Fax: +81 3 5841 4855 ;
Tel: +81 3 5841 4852
b
Department of Pharmacology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan
c
Photon Medical Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan
d
Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan
e
Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Namiki 3-2, Tokorozawa, Japan
f
Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Japan
g
Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui, Takasaki-shi, Gunma 370-0033, Japan
h
JST, PRESTO, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
i
Department of Physiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
j
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
k
Open Innovation Center for Drug Discovery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Org. Biomol. Chem., 2014,12, 8611-8618

DOI: 10.1039/C4OB01270D
Received 19 Jun 2014, Accepted 13 Aug 2014
First published online 14 Aug 2014
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